PhD positions
Ronja Pscheid – In-depth anti-tumour reactivity against haematological and solid tumour cells of αβ-Tcells engineered to express a defined γδTCR (TEGs)
| Institute: | Gadeta B.V. |
| Supervisor: | Dr. Esther Drent |
| Co-Supervisors: | Prof. Dr. Katia Scotlandi and Dr. Annette Künkele |
| Secondments: | IOR (Italy) and Charité (Germany) |
| Enrolment in Doctoral Program: | Cancer Stem Cells and Developmental Biology |
| PhD awarded by: | University Utrecht |
Objectives
Gadeta specializes in the development of innovative cancer immunotherapies, based on ground breaking discoveries of Prof.Dr. Küball regarding the role of γδ T cell receptors (γδ TCRs) in the recognition of haematological and solid tumour cells. The project will focus on in-depth anti- tumour reactivity of different αβ T cells engineered to express a defined γδ TCR (TEGs) targeting multiple tumour entities.
Expected Results
Proof of principle for TEG-therapy in primary and relapse NB and possibly other tumours; identification of targetable mechanisms preventing TEG-mediated killing of NB.