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Available PhD positions

PhD position 5: Paris – Targeting the surface-ome landscape of paediatric brain tumours

Institute:Institute Curie
Supervisor:Dr. Olivier Ayrault
Co-Supervisors:Prof. Dr. Louis Chesler and Dr. Julia Schueler
Secondments:ICR (United Kingdom) and Charles River (Germany)
Enrolment in Doctoral Program:Cancerology
PhD awarded by:Paris-Saclay University

Objectives

Cell-surface proteins are one of the most appealing targets for targeted therapy, as they are present at the surface and often responsible for the activation of major signalling pathways in cancer. Based on our expertise in medulloblastoma (MB) and proteomics (Forget et al, Cancer Cell, 2018), we would like to (i) develop a workflow aiming at characterizing the proteome at the surface of MB cells, (ii) translate this workflow to any type of paediatric tumours, and (iii) develop further strategies targeting the surface-ome of paediatric tumours.

Expected Results

Data generated should allow to (i) specifically target tumour cells (ie. antibody-based approaches, CAR-T cells, etc.), (ii) decipher accessible targetable molecules at the cell surface (receptors, etc.), and also (iii) identify specific biomarkers.