Summerschool Heidelberg September 2022

Monday 19th September:
Location = Conference Center Heidelberg, Carl-Friedrich-Gauß-Ring 5, 69124 Heidelberg

8:30-9:00                      Registration

9:00 – 9:30                   Opening summerschool, overview of the programme
Speakers: Prof. Dr. Jan Molenaar (Máxima), Dr. Marcel Kool (Maxima/KiTZ/DKFZ), Dr. Ina Oehme (KiTZ/DKFZ)

BLOK 1: MOLECULAR TARGETS AND PATHWAYS
Moderator/chair BLOK 1: Valentina Lo Re (Curie) and Jakob Wurth (UZH)

9:30-10:00                    Prof. Dr. Stephan Pfister: “Personalizing pediatric oncology – INFORM experience”

10:00-10:30                 Dr. Ina Oehme: “Functional ex vivo drug screens within the INFORM precision medicine program reveals added value to NGS based target identification”

10:30-10:45                  Babette Hoen (Máxima): “Smart drug screening to identify synergy between conventional          chemotherapy, precision medicines and immunotherapy for B-ALL”

10:45-11:00                  Shanzheng Wang (KiTZ): “R-loops in pediatric brain tumors”

11:00-11:30                  Coffee break

11:30-11:45                  Marta Emperador (KiTZ): “Targeting of the ECM in therapy resistant pediatric tumors”

11:45-12:00                 Negin Razizadeh (LMU): “Targeting ATRX-deficient hepatoblastoma”

12:00-12:15                 Joshua Goulding (Ugent): “Replicative Stress Resistance Modelling and Therapeutic Targeting in Neuroblastoma”

12:15-13:30                  Lunch Break

BLOK 2: EPIGENETICS
Moderator/chair BLOK 2: Joshua Goulding (Ugent) and Babette Hoen (Máxima)

13:30-14:30                  Dr. Jarno Drost (Máxima) and Dr. Ana Banito (KiTZ)
Title: tbd

14:30-14:45                  Charlotte Butterworth (Curie): “A novel approach to decipher the epigenetic evolution of Neuroblastoma”

14:45-15:00                  Jiayou He (Máxima): “Deciphering epigenetic reprogramming in Atypical Teratoid Rhabdoid Tumors (ATRTs)”

15:00-15:15                   Veveeyan Suresh (CCRI): ‘FACS based high throughput drug screening to identify EWS::FLI1 modulatory pathways’

15:15-15:30                  Coffee break

15:30-15:45                  Joaquin Jurado Maqueda (IOR): ‘Exosomes role in the chemoresistance of osteosarcoma cells’

15:45-16:00                  Jakob Wurth (UZH): “Targeting transcriptional core regulatory circuit by epigenetic dependencies”

16:00 – 16:30                break

16:30-18:00                  Supervisory board meeting (hybrid), closed session only for consortium members

Tuesday 20 September :
Location = Conference Center Heidelberg, Carl-Friedrich-Gauß-Ring 5, 69124 Heidelberg

BLOK 3: IMMUNOLOGIE
Moderator/chair BLOK 3: Joaquin Jurado Maqueda (IOR) and Charlotte Butterworth (Curie)

9:00-10:00                    Dr. Judith Wienke (Máxima) and  Dr. Annette Künkele (Charité): “Novel immunotherapies for neuroblastoma: outsmarting the tumor and its microenvironment”

10:00-10:15                  Ronja Pscheid (Gadeta BV): “In-depth anti-tumor reactivity of TEGs towards pediatric cancer”

10:15-10:30.                  Elisa Zappa (Máxima): ““Immune interventions from scRNAseq analysis from debulked neuroblastoma tumors”

10:30-11:00                  Coffee break

11:00-11:15                   Alice Vitali (Charité): “CAR and TCR T therapy: competitor bundle forces. A combinational approach to prevent tumour escape by antigen loss”

11:15-11:30                    Valentina Lo Re (Curie): “Targeting the surface-ome landscape of paediatric tumor”

11:30-11:45                   Alejandro Allo Anido (ICR): Exploring the relation between transcriptional noise and phenotypic plasticity as a source of non-genetic evolution in neuroblastoma

11:45-12:00                  Wrap up and announce parallel sessions and speakers (Jan Molenaar/Marcel Kool)

12:00-13:00                  Lunch Break and ‘Best PhD presentation award’

Theme: New Developments
Chair: Marcel Kool / Jan Molenaar

13:00 – 13:30                Dr. Marcel Kool:  “Molecular classification of pediatric brain tumors and how to translate genomic findings to the clinic”

13:30 – 14:00                Prof. Dr. Frank Westermann

14:00 – 14:30                Prof. Dr. Till Milde: “Waking up Sleeping Beauty – development of low-grade glioma in vitro models”

14:30 – 15:00                Coffee break

15:00 – 15:30                Dr. Ashok Kumar Jayavelu: ‘From bulk to single cell proteomics for precision medicine’

15:30 – 16:00                Prof. Dr. Thomas Grunewald: “Translational genomics and targeted therapy of Ewing sarcoma”

16:00 – 17:00                Meet the speaker – informal drink

Due to limited space, tickets will be given out on a first come, first serve basis. So, register as soon as possible and before Sept 10th, because you don’t want to miss this exciting event!
Registration link: https://forms.gle/8r9kdkH2ZY5KJyez6

This summer school is funded by the Innovation Campus Health & Life Sciences. Learn more on our blog page and here: www.health-life-sciences.de