Alejandro Anido - Development of therapies targeting the oncogenic and immunologic activity of MYCN in neuroblastoma
PhD project 11: neuroblastoma
|Institute:||The Institute of Cancer Research|
|Supervisor:||Prof. Dr. Louis Chesler|
|Co-Supervisors:||Prof. Dr. Frank Speleman and Dr. Esther Drent|
|Doctoral Program:||Cancer Biology|
|Secondments:||Ugent (Belgium) and Roche (Switzerland)|
MYCN is a driver of paediatric cancer, oncogene dependency and immunosuppression. We have developed initial small-molecule drugs and CAR-T therapies targeting MYCN, now entering clinical use. The objective now is to develop synergistic combination therapy with small-molecules and complementary T-cell directed drugs. We will characterize the immunologic and microenvironmental effects of treatment, correlate them with elimination of MYCN transcription and use them to develop rational combination therapy for a clinical trial.
We expect to: 1) develop detailed single-cell transcriptomic and proteomic data on maintenance of tumours and immune- microenvironment by MYCN, 2) develop in-vivo data on impact to tumour microenvironment, tumour progression and survival and 3) test a synergistic small-molecule CAR-T therapy approach for clinical trial.